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Sgt. Bulkyker is correct, I used to do a ton of backpacking and one of the keys is to wear at least two pairs of socks so they slide on each other instead of your skin. We usually used a thin liner...

Have you tried paying attention to your stride length on the treadmill? Your stride may be too short which puts more stress on your calves.

One of the main things to avoid when running on asphalt is hills. Hills tend to place much greater strain on your knees than flat ground. Combine that with the fact that asphalt is worse than dirt...

When you stretch prior to running be sure to take long deep breaths. I usually go for about 5 breaths for each stretch. This also gives you a good measurable way to make sure you are stretching...